Binder syndrome

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Binder syndrome or maxillo-nasal dysplasia can be diagnosed in early gestation. The prominent feature is the small nose with flattening of the fronto-nasal angle. It is frequently associated with other anomalies affecting mostly the fetal skeleton, malformations of the cervical spine, chondrodysplasia punctata and warfarin embryopathy

Reference(s):Cook K, Prefumo F, Presti F, Homfray T, Campbell S. The prenatal diagnosis of Binder syndrome before 24 weeks of gestation: case report. Ultrasound Obstet Gynecol 2000;16(6):578–81. PubMed PMID: 11169356.