Page last updated April 2020

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Current Authors


Cryoglobins are unusual proteins that precipitate out of solution at low temperatures and reversibly re-dissolve on warming. Their presence is associated with:
  • Auto-immune diseases, including:
    • Poststreptococcal glomerulonephritis
    • Rheumatoid arthritis
    • Lupus
    • Sjoegren's syndrome
    • Polyarteritis nodosum
  • Infectious illnesses, including:
    • Mononucleosis
    • Syphilis
    • Cytomegalovirus
    • Leprosy
    • Sarcoidosis
  • Malignancies, specifically:
    • Multiple myeloma
    • Chronic lymphocytic leukemia
    • Lymphosarcoma
  • Liver disease, hemolytic disease, and ulcerative colitis

Normal Values*

Men-Women Negative

*These are general values taken from a variety of sources. The actual normal values may vary from lab to lab and from one type of testing protocol to another.