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Estradiol (Estrogen) is a female hormone, produced primarily in the ovary. The amount of estrogen produced depends on the phase of the menstrual cycle.

Men also produce estradiol, but only very small amounts.

Shortly before ovulation, estradiol levels surge and then fall immediately after ovulation. They then rise again and remain elevated until 2-3 days before menstruation.

  • If pregnancy occurs, the estradiol levels remain elevated. 
  • If pregnancy does not occur, then estradiol levels fall, which, in combination with falling progesterone levels, provoke a menstrual flow.

Elevations found in:

  • Pregnancy
  • Ovulation
  • Second half of the menstrual cycle
  • Congenital adrenal hyperplasia
  • Some hormone-producing tumors of the ovary
  • Polycystic Ovary Syndrome (PCO, Stein-Levinthal Syndrome)
  • Amenorrhea-Galactorrhea Syndrome
  • Liver disease

Decreases found in:

  • Menopause
  • Pituitary failure
  • Adrenal failure
  • Ovarian failure
  • Luteal Phase Deficiency

Normal Values*

Men 13-42 pg/ml 48-154 pmol/L

     (Proliferative Phase)

60-250 pg/ml 220-918 pmol/L
     (Luteal Phase)
75-450 pg/ml 275-1650 pmol/L
<10 pg/ml <40 pmol/L
     (Menopausal on 
       estrogen replacement)
50-100 pg/ml 184-367 pmol/L

*These are general values taken from a variety of sources. The actual normal values may vary from lab to lab and from one type of testing protocol to another.