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ANA (Antinuclear Antibodies)

Antinuclear antibodies are globulins that can react with the nuclei of cells. There is a connection between the presence of these antibodies and the presence of various autoimmune diseases.
  • Most individuals with lupus, scleroderma, and rheumatoid arthritis will have a positive ANA test
  • About a third of individuals with Sjoegren's disease, dermatomyositis and polyarteritis will be positive for ANA
  • Some normal individuals are positive for ANA
  • Some apparently normal individuals who are positive for ANA will, later in life, develop an autoimmune disease
  • A negative ANA is strong evidence against autoimmune disease being present

Normal Values*

Titer 1:10 (1:20 in some labs)

*These are general values taken from a variety of sources. The actual normal values may vary from lab to lab and from one type of testing protocol to another.


Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington DC, 20372-5300, USA